Identification of new Wilms tumour predisposition genes: an exome sequencing study
S Mahamdallie, S Yost, E Poyastro-Pearson… - The Lancet Child & …, 2019 - thelancet.com
Background Wilms tumour is the most common childhood renal cancer and is genetically
heterogeneous. While several Wilms tumour predisposition genes have been identified,
there is strong evidence that further predisposition genes are likely to exist. Our study aim
was to identify new predisposition genes for Wilms tumour. Methods In this exome
sequencing study, we analysed lymphocyte DNA from 890 individuals with Wilms tumour,
including 91 affected individuals from 49 familial Wilms tumour pedigrees. We used the …
heterogeneous. While several Wilms tumour predisposition genes have been identified,
there is strong evidence that further predisposition genes are likely to exist. Our study aim
was to identify new predisposition genes for Wilms tumour. Methods In this exome
sequencing study, we analysed lymphocyte DNA from 890 individuals with Wilms tumour,
including 91 affected individuals from 49 familial Wilms tumour pedigrees. We used the …
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