Women of African ancestry have lower incidence of epithelial ovarian cancer (EOC) yet
worse survival compared to women of European ancestry. We conducted a genome‐wide
association study in African ancestry women with 755 EOC cases, including 537 high‐grade
serous ovarian carcinomas (HGSOC) and 1,235 controls. We identified four novel loci with
suggestive evidence of association with EOC (p< 1× 10− 6), including rs4525119 (intronic to
AKR1C3), rs7643459 (intronic to LOC101927394), rs4286604 (12 kb 3′ of UGT2A2) and …

Epithelial ovarian cancer (EOC) is a rare but deadly disease for which there is notably
poorer survival in women of African Ancestry (AA) compared to women of European
Ancestry (EA). Previous EA-based genome-wide association studies (GWAS) have identified
30 common, low penetrant EOC susceptibility alleles. Using the custom-designed 533,631
SNP Illumina OncoArray and imputation to~ 12 million genetic variants in the 1000
Genomes Phase 3, we conducted a GWAS in 755 AA EOC cases, including 537 high-grade …