Identification of peptides with high red blood cell and hepatocyte binding activity in the Plasmodium falciparum multi-stage invasion proteins: PfSPATR and MCP-1
Plasmodium falciparum multi-stage proteins are involved in vital processes for parasite
survival, which turns them into attractive targets for studies aimed at developing a fully
effective antimalarial vaccine. MCP-1 and PfSPATR are both found in sporozoite and
merozoite forms, and have been associated respectively with invasion of hepatocytes and
red blood cells (RBCs). Binding assays with synthetic peptides derived from these two
important proteins have enabled identifying those sequences binding with high specific …
survival, which turns them into attractive targets for studies aimed at developing a fully
effective antimalarial vaccine. MCP-1 and PfSPATR are both found in sporozoite and
merozoite forms, and have been associated respectively with invasion of hepatocytes and
red blood cells (RBCs). Binding assays with synthetic peptides derived from these two
important proteins have enabled identifying those sequences binding with high specific …
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