Identification of potential tumor differentiation factor (TDF) receptor from steroid-responsive and steroid-resistant breast cancer cells
I Sokolowska, AG Woods, MA Gawinowicz… - Journal of Biological …, 2012 - ASBMB
Tumor differentiation factor (TDF) is a recently discovered protein, produced by the pituitary
gland and secreted into the bloodstream. TDF and TDF-P1, a 20-amino acid peptide
selected from the open reading frame of TDF, induce differentiation in human breast and
prostate cancer cells but not in other cells. TDF protein has no identified site of action or
receptor, and its mechanism of action is unknown. Here, we used TDF-P1 to purify and
identify potential TDF receptor (TDF-R) candidates from MCF7 steroid-responsive breast …
gland and secreted into the bloodstream. TDF and TDF-P1, a 20-amino acid peptide
selected from the open reading frame of TDF, induce differentiation in human breast and
prostate cancer cells but not in other cells. TDF protein has no identified site of action or
receptor, and its mechanism of action is unknown. Here, we used TDF-P1 to purify and
identify potential TDF receptor (TDF-R) candidates from MCF7 steroid-responsive breast …
[PDF][PDF] IDENTIFICATION OF A POTENTIAL TUMOR DIFFERENTIATION FACTOR (TDF) RECEPTOR FROM STEROID-RESPONSIVE AND STEROID-RESISTANT …
Background: Tumor Differentiation Factor (TDF) is a newly identified pituitary protein with no
known receptor. Result: Heat Shock 70 kDa proteins are potential TDF receptor candidates.
Conclusion: TDF acts on breast cells through a novel pathway. Significance: These data
may help elucidate the role of TDF.
known receptor. Result: Heat Shock 70 kDa proteins are potential TDF receptor candidates.
Conclusion: TDF acts on breast cells through a novel pathway. Significance: These data
may help elucidate the role of TDF.
以上显示的是最相近的搜索结果。 查看全部搜索结果