Identification of residues responsible for ligand recognition and regioisomeric selectivity of lysophosphatidic acid receptors expressed in mammalian cells
Y Fujiwara, V Sardar, A Tokumura, D Baker… - Journal of Biological …, 2005 - ASBMB
The endothelial differentiation gene family encodes three highly homologous G protein-
coupled receptors for lysophosphatidic acid (LPA). Based on baculoviral overexpression
studies, differences have been proposed in the structure-activity relationship (SAR) of these
receptors. We have compared the SAR of the individual receptors either overexpressed
transiently at high or at lower levels following stable transfection in LPA-nonresponsive
RH7777 cells. The SAR in transfected RH7777 cells was markedly different from that …
coupled receptors for lysophosphatidic acid (LPA). Based on baculoviral overexpression
studies, differences have been proposed in the structure-activity relationship (SAR) of these
receptors. We have compared the SAR of the individual receptors either overexpressed
transiently at high or at lower levels following stable transfection in LPA-nonresponsive
RH7777 cells. The SAR in transfected RH7777 cells was markedly different from that …
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