Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice* s⃞
Z Su, X Wang, SW Tsaih, A Zhang, A Cox… - Journal of lipid …, 2009 - ASBMB
To evaluate the effect of genetic background on high-density lipoprotein cholesterol (HDL)
levels in Soat1−/− mice, we backcrossed sterol O-acyltransferase 1 (Soat1)−/− mice,
originally reported to have elevated HDL levels, to C57BL/6 mice and constructed a
congenic strain with only a small region (3.3 Mb) of 129 alleles, specifically excluding the
nearby apolipoprotein A-II (Apoa2) gene from 129. HDL levels in these Soat1−/− mice were
no different from C57BL/6, indicating that the passenger gene Apoa2 caused the previously …
levels in Soat1−/− mice, we backcrossed sterol O-acyltransferase 1 (Soat1)−/− mice,
originally reported to have elevated HDL levels, to C57BL/6 mice and constructed a
congenic strain with only a small region (3.3 Mb) of 129 alleles, specifically excluding the
nearby apolipoprotein A-II (Apoa2) gene from 129. HDL levels in these Soat1−/− mice were
no different from C57BL/6, indicating that the passenger gene Apoa2 caused the previously …
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