Immediate myeloid depot for SARS-CoV-2 in the human lung
In the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection, epithelial populations in the distal lung expressing Angiotensin-converting enzyme
2 (ACE2) are infrequent, and therefore, the model of viral expansion and immune cell
engagement remains incompletely understood. Using human lungs to investigate early host-
viral pathogenesis, we found that SARS-CoV-2 had a rapid and specific tropism for myeloid
populations. Human alveolar macrophages (AMs) reliably expressed ACE2 allowing both …
infection, epithelial populations in the distal lung expressing Angiotensin-converting enzyme
2 (ACE2) are infrequent, and therefore, the model of viral expansion and immune cell
engagement remains incompletely understood. Using human lungs to investigate early host-
viral pathogenesis, we found that SARS-CoV-2 had a rapid and specific tropism for myeloid
populations. Human alveolar macrophages (AMs) reliably expressed ACE2 allowing both …
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