Immune cell signaling defects in lupus: activation, anergy and death
GC Tsokos, SNC Liossis - Immunology today, 1999 - cell.com
Immunology today, 1999•cell.com
Recent studies have identified novel aberrations in antigen receptor-mediated signaling
events in lymphocytes from patients with systemic lupus erythematosus. Here, we propose
that in lupus lymphocytes, the receptor-mediated increase in protein tyrosine
phosphorylation and cytoplasmic free Ca 2+ responses, along with T-cell receptor ζ chain
deficiency, might explain the previously described diverse and conflicting immunoregulatory
defects in human lupus.
events in lymphocytes from patients with systemic lupus erythematosus. Here, we propose
that in lupus lymphocytes, the receptor-mediated increase in protein tyrosine
phosphorylation and cytoplasmic free Ca 2+ responses, along with T-cell receptor ζ chain
deficiency, might explain the previously described diverse and conflicting immunoregulatory
defects in human lupus.
Abstract
Recent studies have identified novel aberrations in antigen receptor-mediated signaling events in lymphocytes from patients with systemic lupus erythematosus. Here, we propose that in lupus lymphocytes, the receptor-mediated increase in protein tyrosine phosphorylation and cytoplasmic free Ca2+ responses, along with T-cell receptor ζ chain deficiency, might explain the previously described diverse and conflicting immunoregulatory defects in human lupus.
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