Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge
Epstein-Barr virus (EBV) is a cancer-associated pathogen responsible for 165,000 deaths
annually. EBV is also the etiological agent of infectious mononucleosis and is linked to
multiple sclerosis and rheumatoid arthritis. Thus, an EBV vaccine would have a significant
global health impact. EBV is orally transmitted and has tropism for epithelial and B cells.
Therefore, a vaccine would need to prevent infection of both in the oral cavity. Passive
transfer of monoclonal antibodies against the gH/gL glycoprotein complex prevent …
annually. EBV is also the etiological agent of infectious mononucleosis and is linked to
multiple sclerosis and rheumatoid arthritis. Thus, an EBV vaccine would have a significant
global health impact. EBV is orally transmitted and has tropism for epithelial and B cells.
Therefore, a vaccine would need to prevent infection of both in the oral cavity. Passive
transfer of monoclonal antibodies against the gH/gL glycoprotein complex prevent …
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