Recent studies have suggested that the presence of a c-Kit/c-Kit ligand autocrine loop may
be an important regulator of proliferation and progression of human colorectal cancer,
capable of affecting the prognosis of these patients. If present, the c-Kit alteration may
provide a suitable target for therapy, similar to what has been observed in gastrointestinal
stromal tumors. To determine the incidence of c-Kit expression in human colorectal
carcinomas, we studied the immunohistochemical c-Kit expression in a selection of 126 …