Immunosensors for pesticide analysis: antibody production and sensor development
Critical reviews in biotechnology, 2002•Taylor & Francis
Immunosensors, a type of affinity biosensor, are based on the binding interactions between
an immobilized biomolecule (antibody/antigen) on the electronic transducer surface with the
analyte of interest (antigen/antibody), resulting in a detectable signal. The sensor system
takes advantage of the high selectivity provided by the molecular recognition characteristic
of an antibody, which binds reversibly with a specific antigen. This review article presents
the current status of immunosensors, highlighting their potential benefits and limitations for …
an immobilized biomolecule (antibody/antigen) on the electronic transducer surface with the
analyte of interest (antigen/antibody), resulting in a detectable signal. The sensor system
takes advantage of the high selectivity provided by the molecular recognition characteristic
of an antibody, which binds reversibly with a specific antigen. This review article presents
the current status of immunosensors, highlighting their potential benefits and limitations for …
Abstract
Immunosensors, a type of affinity biosensor, are based on the binding interactions between an immobilized biomolecule (antibody/antigen) on the electronic transducer surface with the analyte of interest (antigen/antibody), resulting in a detectable signal. The sensor system takes advantage of the high selectivity provided by the molecular recognition characteristic of an antibody, which binds reversibly with a specific antigen.
This review article presents the current status of immunosensors, highlighting their potential benefits and limitations for pesticide analysis. The basic criteria for generating specific antibodies against low-molecular-mass pesticides, which are usually nonimmunogenic in nature, are briefly discussed. The article also describes the fundamentals of important transducer technologies and their use in immunosensor development.
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