Immunotherapy for Alzheimer's disease

D Morgan - Journal of internal medicine, 2011 - Wiley Online Library
… Several anti-Aß immunotherapies have reached phase 3 testing, and immunotherapy is
likely to be the first test of the amyloid hypothesis of Alzheimer’s disease. Identifying antibody …

Immunology and immunotherapy of Alzheimer's disease

HL Weiner, D Frenkel - Nature Reviews Immunology, 2006 - nature.com
Immunotherapy in mouse models of Alzheimer's disease by … in some patients with Alzheimer's
disease and was discontinued… models and patients with Alzheimer's disease indicates that …

Immunotherapy for Alzheimer's disease

DS Gelinas, K DaSilva, D Fenili… - Proceedings of the …, 2004 - National Acad Sciences
The utility of vaccine strategies to treat neurodegenerative diseases such as Alzheimer's
disease (AD) may still hold promise. Both active and passive immunization strategies reduced …

Immunotherapy for Alzheimer's disease

T Wisniewski, F Goñi - Biochemical pharmacology, 2014 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia worldwide. In AD the normal
soluble amyloid β (sAβ) peptide is converted into oligomeric/fibrillar Aβ. The oligomeric …

Immunotherapy for Alzheimer's disease: hoops and hurdles

CA Lemere - Molecular neurodegeneration, 2013 - Springer
… or immunotherapy, prevention of Aβ aggregation and promotion of Aβ clearance by …
immunotherapy, and interference of the toxic response to Aβ by neurons by tau immunotherapy

Tau immunotherapy for Alzheimer's disease

JT Pedersen, EM Sigurdsson - Trends in molecular medicine, 2015 - cell.com
Targeting pathological tau protein in Alzheimer's disease (AD) and related tauopathies has
shown great potential in animal models. Given that tau lesions correlate better with the …

Immunotherapy for Alzheimer's disease: past, present and future

B Spencer, E Masliah - Frontiers in aging neuroscience, 2014 - frontiersin.org
Alzheimer’s disease (AD) is an incurable, progressive, neurodegenerative disorder affecting
over 5 million people in the US alone. This neurological disorder is characterized by …

Immunotherapy for Alzheimer's disease: Targeting β-amyloid and beyond

C Song, J Shi, P Zhang, Y Zhang, J Xu, L Zhao… - Translational …, 2022 - Springer
… On the other hand, passive immunotherapy (antibodies) is … In this review, we introduce
immunotherapeutic strategies … the perspectives and challenges of immunotherapies for AD. …

Immunotherapy for Alzheimer's disease

RC Dodel, H Hampel, Y Du - The Lancet Neurology, 2003 - thelancet.com
… murine models of Alzheimer's disease (AD… Immunotherapy approaches represent fascinating
ways to test the amyloid hypothesis and may offer genuine opportunities to modify disease

Amyloid-β immunotherapy for Alzheimer's disease: the end of the beginning

D Schenk - Nature Reviews Neuroscience, 2002 - nature.com
Immunotherapy represents one of the first tests of the amyloid hypothesis in the clinic, and
is … of Alzheimer's disease that offers a genuine opportunity to modify disease progression. …