… Immunotherapy in mouse models of Alzheimer'sdisease by … in some patients with Alzheimer's disease and was discontinued… models and patients with Alzheimer'sdisease indicates that …
DS Gelinas, K DaSilva, D Fenili… - Proceedings of the …, 2004 - National Acad Sciences
The utility of vaccine strategies to treat neurodegenerative diseases such as Alzheimer's disease (AD) may still hold promise. Both active and passive immunization strategies reduced …
Alzheimer'sdisease (AD) is the most common cause of dementia worldwide. In AD the normal soluble amyloid β (sAβ) peptide is converted into oligomeric/fibrillar Aβ. The oligomeric …
CA Lemere - Molecular neurodegeneration, 2013 - Springer
… or immunotherapy, prevention of Aβ aggregation and promotion of Aβ clearance by … immunotherapy, and interference of the toxic response to Aβ by neurons by tau immunotherapy…
Targeting pathological tau protein in Alzheimer'sdisease (AD) and related tauopathies has shown great potential in animal models. Given that tau lesions correlate better with the …
B Spencer, E Masliah - Frontiers in aging neuroscience, 2014 - frontiersin.org
Alzheimer’s disease (AD) is an incurable, progressive, neurodegenerative disorder affecting over 5 million people in the US alone. This neurological disorder is characterized by …
C Song, J Shi, P Zhang, Y Zhang, J Xu, L Zhao… - Translational …, 2022 - Springer
… On the other hand, passive immunotherapy (antibodies) is … In this review, we introduce immunotherapeutic strategies … the perspectives and challenges of immunotherapies for AD. …
… murine models of Alzheimer'sdisease (AD… Immunotherapy approaches represent fascinating ways to test the amyloid hypothesis and may offer genuine opportunities to modify disease …
D Schenk - Nature Reviews Neuroscience, 2002 - nature.com
… Immunotherapy represents one of the first tests of the amyloid hypothesis in the clinic, and is … of Alzheimer'sdisease that offers a genuine opportunity to modify disease progression. …