Background

Asthma is a prevalent chronic health condition, affecting approximate 7.7% of adults working age that is characterized by variable respiratory symptoms and variable airflow limitation induced by chronic airway inflammation. 1 Acute exacerbations are characterized by decrease in expiratory airflow (PEF or FEV1) that may range from mild to life threatening state as according to measurement of PEF, FEV12, 3 as well as the need to use systemic corticosteroids. 4, 5 Normally, about 97 percent of the oxygen transported from the lungs to the tissues in the red blood cells based on Oxygen–Hemoglobin Dissociation Curve. 6 WHO had defined anemia as less than 130 g/L for men and 120 g/L for women, without the distinction between age and race. 7

Iron deficiency is also one of the most common nutritional deficiencies is thought to be more prevalent in population at greatest risk for asthma assuming that these tow conditions may be linked. 8 In animal models, a low iron diet resulted in pronounced asthma in mouse model of allergic asthma, that is mediated by increased mast cell reactivity in the setting of low iron. 9