Impact of glucocorticoids and chronic stress on progression of Parkinson's disease

A Kibel, I Drenjančević-Perić - Medical hypotheses, 2008 - Elsevier
Parkinson's disease, a chronic progressive neurodegenerative disorder, has a mainly
unknown multifactorial etiology. It is characterized by progressive degeneration of
dopaminergic neurons. Chronic stress, a condition mediated by elevated concentrations of
glucocorticoids over an extended period of time, has been shown to be unfavourable for
neurons and to cause damage and neuronal loss in certain brain areas. Glucocorticoids are
most probably not toxic in a direct manner, but can make neuronal damage through several …
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