Background: Given the rarity and nuance of soft-tissue sarcoma management, current clinical guidelines call for treatment at experienced treatment facilities. However, the actual impact of sarcoma expertise on oncologic outcomes is unclear. This study evaluates the impact of institutional treatment volume on outcomes among patients with soft-tissue sarcoma. Methods: We identified 14,255 patients within the National Cancer Database who underwent resection for stage I-III extremity or retroperitoneal soft-tissue sarcoma between 2004 and 2015. Differences in patterns of care and outcomes were compared between high volume and low volume treatment centers. Outcomes included patterns of chemotherapy and radiation therapy, surgical margin status, and overall survival. Multivariable logistic and Cox regression models were used to determine the impact of treatment center volume while controlling for potential confounders. Results: Patients treated at high volume centers had lower rates of positive surgical margins (odds ratio [OR] 0.68; 95% CI 0.61-0.75; p < 0.0001), increased use of chemotherapy (OR 1.33; 95% CI 1.18-1.5; p < 0.0001), and increased use of neoadjuvant radiation (OR 1.94; 95% CI 1.72-2.2; p < 0.0001). Patients treated at high volume centers had an 8% decreased risk of death compared to those treated at low volume centers (hazard ratio [HR] 0.92; 95% CI 0.85-0.99; p = 0.045). The association between high volume centers and outcomes differed by treatment center type, with high volume academic institutions showing the strongest improvement in survival (HR 0.89; 95% CI 0.81-0.97; p = 0.004), and high volume community centers showing decreased survival (HR 1.9; 95% CI 1.3-2.9; p = 0.004). Conclusions: This study demonstrates different patterns of care and improved outcomes for soft-tissue sarcoma patients treated at high volume treatment centers. Though patient selection bias could influence these associations, overall these findings affirm the suggested benefits of receiving care at experienced treatment centers.