Implementing a functional precision medicine tumor board for acute myeloid leukemia

D Malani, A Kumar, O Brück, M Kontro, B Yadav… - Cancer discovery, 2022 - AACR
implement the results in real time for clinical translation, we designed a multidisciplinary
functional precision medicine tumor board … in highlighting the cancer-specific efficacy of drugs; (ii…

Functional precision medicine provides clinical benefit in advanced aggressive hematologic cancers and identifies exceptional responders

C Kornauth, T Pemovska, GI Vladimer, G Bayer… - Cancer discovery, 2022 - AACR
… This is the first precision medicine trial using a functional … based on functional dependencies
of each patient's cancer. … , are discussed in a dedicated tumor board with patients treated …

Application of precision medicine in clinical routine in haematology—challenges and opportunities

T Wästerlid, L Cavelier, C Haferlach… - … of Internal Medicine, 2022 - Wiley Online Library
… risk stratification of acute myeloid leukaemia and myelodysplastic … optimal treatment using
functional precision medicine (FPM; … , the molecular tumour board made recommendations for …

Precision medicine treatment in acute myeloid leukemia using prospective genomic profiling: feasibility and preliminary efficacy of the Beat AML Master Trial

A Burd, RL Levine, AS Ruppert, AS Mims, U Borate… - Nature medicine, 2020 - nature.com
precision medicine in AML and sets the stage to extend this same approach to younger patients
with this disease and other cancers … overall survival as a function of the elected treatment …

Explainable artificial intelligence for precision medicine in acute myeloid leukemia

M Gimeno, E San José-Enériz, S Villar… - Frontiers in …, 2022 - frontiersin.org
… of using XAI models in the finding of new personalized … (AML) as a disease model, a highly
heterogeneous type of cancer that … of cell lines loss-of-function datasets. Nevertheless, even …

Novel precision medicine approaches and treatment strategies in hematological malignancies

R Rosenquist, E Bernard, T Erkers… - … of Internal Medicine, 2023 - Wiley Online Library
myeloid (myelodysplastic syndrome, acute myeloid leukemia… of the first fields in cancer to
develop and implement PM tools, … Implementing a Functional Precision Medicine Tumor Board

Precision medicine for cancer with next-generation functional diagnostics

AA Friedman, A Letai, DE Fisher, KT Flaherty - Nature Reviews Cancer, 2015 - nature.com
… breast cancer using an improved CTC microfluidic chip that was shown to enrich tumour cells
for … -ITD)-positive acute myeloid leukaemia (AML) were killed by drugs that are all known to …

Molecular tumor boards: The next step towards precision therapy in cancer care

A Liu, P Vicenzi, I Sharma, K Orr, C Teller, M Koentz… - Hematology …, 2023 - mdpi.com
… country are implementing molecular tumor boards (MTBs). … gained from the individual practice
of precision medicine [7]. Here… male diagnosed with CNS3 acute myeloid leukemia (AML). …

Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia

T Pemovska, M Kontro, B Yadav, H Edgren, S Eldfors… - Cancer discovery, 2013 - AACR
… a comprehensive functional strategy to directly determine the drug dependency of cancer
cells … Indeed, we carried out a pilot test for the implementation of optimized therapies for 8 …

Feasibility of functional precision medicine for guiding treatment of relapsed or refractory pediatric cancers

AM Acanda De La Rocha, NE Berlow, M Fader… - Nature Medicine, 2024 - nature.com
… The implementation of functional precision medicine (FPM), … of returning data to an FPM
tumor board (FPMTB) in a clinically … acute lymphoblastic leukemias (ALLs), three acute myeloid