The training of scientists for immunology can begin in undergraduate classes. Here we report our experience in the development and application of an inquiry-based learning activity with these characteristics for students of the biological sciences course. The results showed that the groups of students, when performing the inquiry-based learning activity, mobilize important epistemic operations for the construction of analyses of justifications and conclusions of the activity in various levels of epistemic status. The approach to immunology topics can be associated with an inquiry-based learning, with simple activities, low cost and that mobilize important skills of scientific literacy for the basic training of one in the field of immunology research.