Improved core genes prediction for constructing well-supported phylogenetic trees in large sets of plant species

B AlKindy, H Al-Nayyef, C Guyeux, JF Couchot… - … , IWBBIO 2015, Granada …, 2015 - Springer
Bioinformatics and Biomedical Engineering: Third International Conference …, 2015Springer
The way to infer well-supported phylogenetic trees that precisely reflect the evolutionary
process is a challenging task that completely depends on the way the related core genes
have been found. In previous computational biology studies, many similarity based
algorithms, mainly dependent on calculating sequence alignment matrices, have been
proposed to find them. In these kinds of approaches, a significantly high similarity score
between two coding sequences extracted from a given annotation tool means that one has …
Abstract
The way to infer well-supported phylogenetic trees that precisely reflect the evolutionary process is a challenging task that completely depends on the way the related core genes have been found. In previous computational biology studies, many similarity based algorithms, mainly dependent on calculating sequence alignment matrices, have been proposed to find them. In these kinds of approaches, a significantly high similarity score between two coding sequences extracted from a given annotation tool means that one has the same genes. In a previous work article, we presented a quality test approach (QTA) that improves the core genes quality by combining two annotation tools (namely NCBI, a partially human-curated database, and DOGMA, an efficient annotation algorithm for chloroplasts). This method takes the advantages from both sequence similarity and gene features to guarantee that the core genome contains correct and well-clustered coding sequences (i.e., genes). We then show in this article how useful are such well-defined core genes for biomolecular phylogenetic reconstructions, by investigating various subsets of core genes at various family or genus levels, leading to subtrees with strong bootstraps that are finally merged in a well-supported supertree.
Springer
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