The efficacy of a teaching sequence designed for a specific content of learning of electrochemistry is described in this paper. The design of the teaching draws upon theoretical insights into perspectives on learning and empirical studies to improve the teaching of this topic. A case study involving two classes, the experimental and baseline classes was carried out for 16-year-old Malaysian upper secondary school students. In addition, eight classes of similar age in eight different schools served as convenience samples (reference groups) were selected in order to compare the differences on their conceptual understanding in a wider sample. The evaluation of students' responses in one of the items in the post diagnostic test shows that there were significant differences in the experimental class students' performances in comparison to the baseline class students and the convenience samples. The finding indicates that the tools designed in the teaching sequence are able to be utilized