Improving solubility and chemical stability of natural compounds for medicinal use by incorporation into liposomes
M Coimbra, B Isacchi, L van Bloois, JS Torano… - International journal of …, 2011 - Elsevier
Natural bioactive compounds have been studied for a long time for their chemopreventive
and therapeutic potential in several chronic inflammatory diseases, including cancer.
However, their physicochemical properties generally result in poor chemical stability and
lack of in vivo bioavailability. Very few human clinical trials have addressed absorption,
distribution, metabolism, and excretion of these compounds in relation to efficacy. This limits
the use of these valuable natural compounds in the clinic. In this study, we examined caffeic …
and therapeutic potential in several chronic inflammatory diseases, including cancer.
However, their physicochemical properties generally result in poor chemical stability and
lack of in vivo bioavailability. Very few human clinical trials have addressed absorption,
distribution, metabolism, and excretion of these compounds in relation to efficacy. This limits
the use of these valuable natural compounds in the clinic. In this study, we examined caffeic …
[PDF][PDF] Improving solubility and chemical stability of natural compounds for medicinal use by incorporation into liposomes
M Coimbraa, B Isacchi, L Bloois, J Toranoc… - International Journal of …, 2011 - academia.edu
abstract Natural bioactive compounds have been studied for a long time for their
chemopreventive and therapeutic potential in several chronic inflammatory diseases,
including cancer. However, their physicochemical properties generally result in poor
chemical stability and lack of in vivo bioavailability. Very few human clinical trials have
addressed absorption, distribution, metabolism, and excretion of these compounds in
relation to efficacy. This limits the use of these valuable natural compounds in the clinic. In …
chemopreventive and therapeutic potential in several chronic inflammatory diseases,
including cancer. However, their physicochemical properties generally result in poor
chemical stability and lack of in vivo bioavailability. Very few human clinical trials have
addressed absorption, distribution, metabolism, and excretion of these compounds in
relation to efficacy. This limits the use of these valuable natural compounds in the clinic. In …
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