In silico drug discovery of Acetylcholinesterase and Butyrylcholinesterase enzymes inhibitors based on Quantitative Structure-Activity Relationship (QSAR) and drug …
In the last years, in order to achieve a better treatment of Alzheimer's disease (AD), much
focus has been put on the development of cholinesterase (Acetylcholinesterase and
Butyrylcholinesterase) inhibitor drugs. Thus, the aim of this study is to discover promising
active compounds for Acetylcholinesterase and Butyrylcholinesterase enzymes inhibitors
based on QSAR model and drug-likeness evaluation. In this study, a series of DL0410 and
its 50 derivatives are accounted for the set up of two QSAR models. This allows an …
focus has been put on the development of cholinesterase (Acetylcholinesterase and
Butyrylcholinesterase) inhibitor drugs. Thus, the aim of this study is to discover promising
active compounds for Acetylcholinesterase and Butyrylcholinesterase enzymes inhibitors
based on QSAR model and drug-likeness evaluation. In this study, a series of DL0410 and
its 50 derivatives are accounted for the set up of two QSAR models. This allows an …
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