Direct mineral dating is critical for thorough understanding of the genesis of hydrothermal mineralizations, ore forming processes and events of fracturing and related fluid-rock interaction. Since minerals of suitable type and sample volume for conventional techniques can be rare, development of high-precision in situ Rb-Sr dating of common rock-forming minerals such as micas, feldspars and calcite offers possibilities to gain temporal constraints of a wide variety of geological features with detailed spatial and depth resolution. This technique separates ⁸⁷Sr from ⁸⁷Rb by introducing a reaction gas between two quadropoles in a LA-ICP-MS system. In this study, in situ Rb-Sr geochronology distinguishes the timing of several different fracture-controlled hydrothermal events: 1 and 2) greisen mineralizations and associated far-field hydrothermal veins adjacent to a granite intrusion, 3) reactivation events within a mylonite shear zone and 4) low-temperature precipitation from saline organic-rich brines in thin veinlets. We demonstrate that in situ Rb-Sr dating is feasible for a broad range of mineral assemblages, textures, temperatures and ages, emphasizing the impending use of this new method in ore deposit exploration and many other research fields.