[HTML][HTML] In vitro and in vivo anthelmintic effects of Caesalpinia bonducella (L.) Roxb. leaf extract on Hymenolepis diminuta (Cestoda) and Syphacia obvelata …
Background: Leaves of Caesalpinia bonducella (L.) Roxb. have been traditionally used as
an herbal remedy to treat the intestinal helminthic infections in traditional medicine of India.
Aim: This study was undertaken to evaluate the potential in vitro and in vivo anthelmintic
effects of C. bonducella leaf extract against Syphacia obvelata (Nematoda) and
Hymenolepis diminuta (Cestoda). Materials and Methods: The in vitro anthelmintic activity of
the extract was investigated on adult worms of S. obvelata (Nematoda) and H. diminuta …
an herbal remedy to treat the intestinal helminthic infections in traditional medicine of India.
Aim: This study was undertaken to evaluate the potential in vitro and in vivo anthelmintic
effects of C. bonducella leaf extract against Syphacia obvelata (Nematoda) and
Hymenolepis diminuta (Cestoda). Materials and Methods: The in vitro anthelmintic activity of
the extract was investigated on adult worms of S. obvelata (Nematoda) and H. diminuta …
Abstract
Background:
Leaves of Caesalpinia bonducella (L.) Roxb. have been traditionally used as an herbal remedy to treat the intestinal helminthic infections in traditional medicine of India.
Aim:
This study was undertaken to evaluate the potential in vitro and in vivo anthelmintic effects of C. bonducella leaf extract against Syphacia obvelata (Nematoda) and Hymenolepis diminuta (Cestoda).
Materials and Methods:
The in vitro anthelmintic activity of the extract was investigated on adult worms of S. obvelata (Nematoda) and H. diminuta (Cestoda) in terms of physical motility and mortality of parasites. The in vivo study was performed in H. diminuta-rat model and S. obvelata-mice model, by monitoring the egg per gram of feces count and worm count of animals following the treatment with different doses of plant extract.
Results:
The study recorded significant and dose-dependent anthelmintic effects of the extract on both the parasites. In the in vitro study, 30 mg/ml concentration of extract caused mortality of H. diminuta in 2.5±0.2 h and S. obvelata in 3.57±0.16 h. In the in vivo study, the extract showed a comparatively better efficacy on S. obvelata, where its 800 mg/kg dose revealed 93% reduction of worm load in mice, as compared to 85% worm load reduction of H. diminuta in rats.
Conclusions:
The findings suggest that leaf extract of C. bonducella possesses significant anthelmintic effects and supports its use as an anthelmintic in traditional medicine. This appears to be the first report of in vivo anthelmintic activity of C. bonducella against these parasites.
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