In vitro drug release and ex vivo percutaneous absorption of resveratrol cream using HPLC with zirconized silica stationary phase
HC Polonini, C de Almeida Bastos… - … of Chromatography B, 2014 - Elsevier
Since the designs of optimal formulations for resveratrol permeation via the skin are lacking,
the aim of this study was to establish the profile of resveratrol permeability into and across
human skin. For that, a laboratory-made chromatographic column was used (Zr-PMODS),
with its performance being compared to a traditional C18 column. In vitro drug release was
conducted with polysulfone membranes, and the flux (JS) was 30.49 μg cm− 2 h− 1), with a
lag time (LT) of 0.04 h, following a pseudo-first-order kinetics. For ex vivo percutaneous …
the aim of this study was to establish the profile of resveratrol permeability into and across
human skin. For that, a laboratory-made chromatographic column was used (Zr-PMODS),
with its performance being compared to a traditional C18 column. In vitro drug release was
conducted with polysulfone membranes, and the flux (JS) was 30.49 μg cm− 2 h− 1), with a
lag time (LT) of 0.04 h, following a pseudo-first-order kinetics. For ex vivo percutaneous …
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