In vitro ultrasound-mediated leakage from phospholipid vesicles

M Pong, S Umchid, AJ Guarino, PA Lewin, J Litniewski… - Ultrasonics, 2006 - Elsevier
Interest in using ultrasound energy in wound management and intracellular drug delivery
has been growing rapidly. Development and treatment optimization of such non-diagnostic
applications requires a fundamental understanding of interactions between the acoustic
wave and phospholipid membranes, be they cell membranes or liposome bilayers. This
work investigates the changes in membrane permeation (leakage mimicking drug release)
in vitro during exposure to ultrasound applied in two frequency ranges:“conventional”(1MHz …
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