In vivo degradation of silicones

L Garrido, B Pfleiderer, M Papisov… - Magnetic resonance in …, 1993 - Wiley Online Library
… We have found that the amount of free polymer present in the silicone gel-filled implants
included in this study was about 28% wlw. The 29Si NMR spectrum of the silicone gel from an …

Migration and biodegradation of free silicone from silicone gel‐filled implants after long‐term implantation

B Pfleiderer, JL Ackerman… - Magnetic resonance in …, 1993 - Wiley Online Library
… this in vivo degradation, especially in the case of implant rupture. Additionally, small
concentrations of fat in the silicone … These findings may assist in evaluating the implant integrity …

Silicone degradation reactions

C Batich, D DePalma, J Marotta, G Latorre - Immunology of silicones, 1996 - Springer
… elevated temperature study and the in vivo environment may vary, however, it is very likely
that the hydrolysis reaction occurs on the surface relatively slowly over a period of. roughly. …

Degradation of biomedical polydimethylsiloxanes during exposure to in vivo biofilm environment monitored by FE‐SEM, ATR‐FTIR, and MALDI‐TOF MS

P Kaali, D Momcilovic, A Markström… - Journal of Applied …, 2010 - Wiley Online Library
in medical devices are usually requested to be inert to degradation. This article describes that
… irreversible changes were observed in silicone surfaces exposed to in vivo biofilms even if …

Biodegradation of polysiloxanes in lymph nodes of rats measured with 29Si NMR

B Pfleiderer, A Moore, E Tokareva, JL Ackerman… - Biomaterials, 1999 - Elsevier
… gel-filled implant are used to investigate the reactivity of silicones in vivo. … silicone gel-filled
implants are biotransformed in the lymph nodes, but high molecular weight polymer degrades

In vitro degradation of polydimethylsiloxanes in breast implant applications

NG Ramião, PS Martins, ML Barroso… - Journal of applied …, 2017 - journals.sagepub.com
… To evaluate the potential impact of in vivo degradation on the … tension testing and in vitro
degradation was carried out with … Goldberg EP Degradation of physical properties of silicone gel …

Study of aging of silicone rubber biomaterials with NMR

B Pfleiderer, P Xu, JL Ackerman… - Journal of biomedical …, 1995 - Wiley Online Library
… This is an indication of the reactivity of silicone in vivo. The experimental details are … It
should be noted that we found some silicone and a low concentration of its degradation by-…

In vivo contaminant partitioning to silicone implants: Implications for use in biomonitoring and body burden

SG O'Connell, NI Kerkvliet, S Carozza… - Environment …, 2015 - Elsevier
… a wide variety of toxicants in human silicone implants, and measuring the in vivo absorption
of contaminants into silicone and surrounding tissue in an animal model. In the first study, …

Biodegradation of the outer silicone insulation of endocardial leads

A Kołodzińska, A Kutarski, M Kozłowska… - Circulation …, 2013 - Am Heart Assoc
in the degradation of the silicone insulation in an in vitro study and to compare the results
with in vivo outer silicone insulation damage in … that in vivo abrasions of silicone create a safe …

Detection of silicone migration and biodegradation with NMR

L Garrido, A Bogdanova, LL Cheng, B Pfleiderer… - … of Silicones, 1996 - Springer
… , degradation, etc.[21,22]. Thus, we have used a combination of in vivo IH NMR localized
spectroscopy and in … of silicones in animal models and humans. The results have shown that …