In vivo epigenome editing and transcriptional modulation using CRISPR technology
The rapid advancement of CRISPR technology has enabled targeted epigenome editing
and transcriptional modulation in the native chromatin context. However, only a few studies
have reported the successful editing of the epigenome in adult animals in contrast to the
rapidly growing number of in vivo genome editing over the past few years. In this review, we
discuss the challenges facing in vivo epigenome editing and new strategies to overcome the
huddles. The biggest challenge has been the difficulty in packaging dCas9 fusion proteins …
and transcriptional modulation in the native chromatin context. However, only a few studies
have reported the successful editing of the epigenome in adult animals in contrast to the
rapidly growing number of in vivo genome editing over the past few years. In this review, we
discuss the challenges facing in vivo epigenome editing and new strategies to overcome the
huddles. The biggest challenge has been the difficulty in packaging dCas9 fusion proteins …
In vivo epigenome editing and transcriptional modulation using CRISPR technology.
LCH Lau CiaHin, SYS Suh YouSin - 2018 - cabidigitallibrary.org
The rapid advancement of CRISPR technology has enabled targeted epigenome editing
and transcriptional modulation in the native chromatin context. However, only a few studies
have reported the successful editing of the epigenome in adult animals in contrast to the
rapidly growing number of in vivo genome editing over the past few years. In this review, we
discuss the challenges facing in vivo epigenome editing and new strategies to overcome the
huddles. The biggest challenge has been the difficulty in packaging dCas9 fusion proteins …
and transcriptional modulation in the native chromatin context. However, only a few studies
have reported the successful editing of the epigenome in adult animals in contrast to the
rapidly growing number of in vivo genome editing over the past few years. In this review, we
discuss the challenges facing in vivo epigenome editing and new strategies to overcome the
huddles. The biggest challenge has been the difficulty in packaging dCas9 fusion proteins …
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