In vivo monitoring of cerebral agmatine by microdialysis and capillary electrophoresis
Agmatine is a putative neurotransmitter in the brain. Current analytical techniques do not
allow the detection of agmatine in extracellular fluid, making it difficult to study its
physiological role. However, a new method for in vivo monitoring agmatine in the brain was
developed. Capillary zone electrophoresis and laser induced fluorescence detection (CZE–
LIFD) was used to measure nanomolar concentrations of agmatine in submicroliter sample
volumes. This analytical technique proved to detect 0.49 attomole of agmatine improving the …
allow the detection of agmatine in extracellular fluid, making it difficult to study its
physiological role. However, a new method for in vivo monitoring agmatine in the brain was
developed. Capillary zone electrophoresis and laser induced fluorescence detection (CZE–
LIFD) was used to measure nanomolar concentrations of agmatine in submicroliter sample
volumes. This analytical technique proved to detect 0.49 attomole of agmatine improving the …
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