Targeting bcl-2 by Triplex-Forming Oligonucleotide—A Promising Carrier for Gene–Radiotherapy

C Shen, D Rattat, A Buck, G Mehrke… - Cancer Biotherapy …, 2003 - liebertpub.com
… a stable triplex and to inhibit bcl-2 gene transcription in vitro. … A 0.8 ml sample of a generator
elute (containing up to 30 mCi Na[… The high binding affinity of the 20 nt oligonucleotides

In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom

S Noonberg, AC Hunt - Biotechnology Advances, 1997 - elibrary.ru
… to accomplish the delivery of oligonucleotides. Also encompassed by the present invention
are methods for screening oligonucleotide sequences that are candidates for triplex formation…

… the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal …

M Egli, G Minasov, V Tereshko, PS Pallan… - Biochemistry, 2005 - ACS Publications
… The binding affinity of 2‘-O-modified oligonucleotides to the target RNA was determined
by … in combination with cholesterol conjugation in an in vivo application ( 36) have shown …

[图书][B] Intracellular generation of RNA oligonucleotides for antisense and triplex gene regulation

SB Noonberg - 1994 - search.proquest.com
Triplex blotting with in vitro generated RNA oligonucleotidesBinding affinity of triplex-forming
oligonucleotides in 1 mM … , characterization, and testing of another method of cellular ON …

Sequence-defined oligonucleotides as potential therapeutics

MD Matteucci, N Bischofberger - Annual Reports in Medicinal Chemistry, 1991 - Elsevier
… The methods for analyzing binding affinity and biological data … ) EDTA as a free radical
generator under the appropriate redox … The inhibition of DNA binding proteins by triplex formation …

Applications of triplex DNA nanostructures in sensor development

PY Lin, R Chi, YL Wu, JA Ho - Analytical and Bioanalytical Chemistry, 2022 - Springer
… A stem-forming oligonucleotide (sfO) was involved in binding … , such as preparation of
nanoparticles as signal generators. … sensors offer superior binding affinity toward their ligands with …

Radiolabelled oligonucleotides for imaging of gene expression with PET

G Lendvai, S Estrada… - Current medicinal …, 2009 - ingentaconnect.com
… They can form very stable duplexes or triplexes with nucleic … (in contrast, PS decreased
binding affinity is caused by the … Generator available radiometals may be preferable to costly …

Recent advancements in aptamer-bioconjugates: sharpening stones for breast and prostate cancers targeting

S Maghsoudi, BT Shahraki, N Rabiee, R Afshari… - Journal of Drug Delivery …, 2019 - Elsevier
… for exploring high-affinity oligonucleotide ligand libraries by the … loaded with a-particle
generator 225 Ac selectively killed … and synthetic oligonucleotide moleclules isolated in vitro

Parallel Clamps and Polypurine Hairpins (PPRH) for Gene Silencing and Triplex-Affinity Capture: Design, Synthesis, and Use

A Aviñó Andrés, R Eritja i Casadellà… - … 2019, vol. 77, num. 1, p …, 2019 - diposit.ub.edu
… Nucleic acid triplexes are formed when a DNA or RNA oligonucleotide binds to a polypurine…
This will allow having a broader spectrum of PPRH sequences for screening of their …

Consequences of replacing the DNA 3 '-oxygen by an amino group: High-resolution crystal structure of a fully modified N3 '→ P5 'phosphoramidate DNA Dodecamer …

V Tereshko, S Gryaznov, M Egli - Journal of the American …, 1998 - ACS Publications
… and DNA- or RNA-binding affinities, only a few modifications … DNA oligonucleotides cannot
form stable triplexes with … in vitro was observed with phosphoramidate oligonucleotides