… reprogramming factors in vivo leads to hepatic and intestinal … weight and contributing to
premature death (within 1 week). … in both liver and intestine, we reduced the early lethality and …

… hepatic and intestinal dysfunctions, not tumor or teratoma formation, are the major causes of
early mortality in the reprogrammed … adverse effects associated with in vivo reprogramming, …

… in vivo ameliorates cellular and physiological hallmarks of … premature death of animals.
Subsequent studies provided evidence supporting the beneficial effects of partial reprogramming …

… proteins to permit the transcriptional reprogramming required … To identify the chromatin-associated
genes that could be … ) mice that experienced chronic liver damage due to a deficiency …

… to extreme toxicity, we 144 decided to induce in vivo reprogramming in C. elegans during …
In vivo reprogramming leads to premature death linked to hepatic and 601 intestinal failure. …

… that the phenotypes associated with in vivo reprogramming in the 258 … vivo reprogramming
results in hepatic and intestinal dysfunction, 272 representing a major cause of early mortality…

… Similar to mice, 31 expression of the reprogramming factors leads to premature death with
… In vivo reprogramming leads to premature death linked to hepatic and 601 intestinal failure. …

… Diseases associated with aging are now the leading causes … may result in liver and
intestinal failure in mice 67 . When … results of in vivo cyclic reprogramming studies, in vitro cyclic …

… to extreme toxicity, we 144 decided to induce in vivo reprogramming in C. elegans during …
In vivo reprogramming leads to premature death linked to hepatic and 601 intestinal failure. …

… We know that many neurological age-related diseases, such as Alzheimer's … vivo induction
of OSKM continuously causes hepatic and intestinal dysfunction leading to premature death (…