[HTML][HTML] Increased CD3+ T cells with a low FOXP3+/CD8+ T cell ratio can predict anti-PD-1 therapeutic response in non-small cell lung cancer patients
H Kim, HJ Kwon, YB Han, SY Park, ES Kim, SH Kim… - Modern Pathology, 2019 - Elsevier
To determine whether tumor microenvironments affect the clinical response to anti-PD-1
therapy in non-small cell lung cancer, we investigated the expression level of PD-L1 and
tumor infiltrating lymphocytes and elucidate their predictive role. Thirty-eight pretreatment
and two post-treatment specimens from 36 advanced, treatment-refractory non-small cell
lung cancer patients who underwent PD-1 blockade therapy were analyzed. PD-L1
expression by tumor cells and the distribution of CD3, CD8, CD4, FOXP3 and PD-1 positive …
therapy in non-small cell lung cancer, we investigated the expression level of PD-L1 and
tumor infiltrating lymphocytes and elucidate their predictive role. Thirty-eight pretreatment
and two post-treatment specimens from 36 advanced, treatment-refractory non-small cell
lung cancer patients who underwent PD-1 blockade therapy were analyzed. PD-L1
expression by tumor cells and the distribution of CD3, CD8, CD4, FOXP3 and PD-1 positive …
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