It is well known that during diarrhea episodes decreased cyclosporine and tacrolimus levels
are often observed, usually requiring an increase in dose. An increase in tacrolimus trough
levels is infrequently recognized as a potential cause of the adverse effect of severe
diarrhea. Herein, we report the case of a renal transplant patient who displayed increased
tacrolimus trough levels during an episode of gastroenteritis with severe diarrhea. The
patient is 32-year-old male who received a renal transplant from his mother …