Independent and interactive effect of CYPs and GSTs genetic variants and tobacco smoking on the risk of non-small cell lung carcinoma
Background CYP and GST gene families detoxify tobacco carcinogens and have been
linked to the risk of non-small cell lung carcinoma (NSCLC). Aim Independent and combined
effects of CYP and GST genetic variations and smoking on the risk of non-small cell lung
carcinoma (NSCLC) and its sub-histological types. Methods We modelled an epistatic
interaction via the effects of particular genotypes in two genes as OR (odds ratio), OR1, and
OR2, a combination of both genotypes were characterized as OR combine. In contrast, the …
linked to the risk of non-small cell lung carcinoma (NSCLC). Aim Independent and combined
effects of CYP and GST genetic variations and smoking on the risk of non-small cell lung
carcinoma (NSCLC) and its sub-histological types. Methods We modelled an epistatic
interaction via the effects of particular genotypes in two genes as OR (odds ratio), OR1, and
OR2, a combination of both genotypes were characterized as OR combine. In contrast, the …
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