Independent and reproducible hippocampal radiomic biomarkers for multisite Alzheimer's disease: diagnosis, longitudinal progress and biological basis

K Zhao, Y Ding, Y Han, Y Fan, AF Alexander-Bloch… - Science Bulletin, 2020 - Elsevier
Hippocampal morphological change is one of the main hallmarks of Alzheimer's disease
(AD). However, whether hippocampal radiomic features are robust as predictors of
progression from mild cognitive impairment (MCI) to AD dementia and whether these
features provide any neurobiological foundation remains unclear. The primary aim of this
study was to verify whether hippocampal radiomic features can serve as robust magnetic
resonance imaging (MRI) markers for AD. Multivariate classifier-based support vector …
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