Independent component analysis uncovers the landscape of the bladder tumor transcriptome and reveals insights into luminal and basal subtypes

A Biton, I Bernard-Pierrot, Y Lou, C Krucker… - Cell reports, 2014 - cell.com
independent component analysis (ICA) to bladder cancer transcriptome data sets and interpreted
the components … of the components retrieved from our reference bladder tumor set (CIT …

[PDF][PDF] Independent Component Analysis Uncovers the Landscape of the Bladder Tumor Transcriptome and Reveals Insights into Luminal and Basal Subtypes

C Rubio-Perez, N Lopez-Bigas, A Kamoun… - Cell …, 2014 - researchgate.net
… We show here that by applying ICA to bladder cancer transcriptome data sets, exploiting …
applied to multiple cancer types, it is possible to obtain insights into bladder carcinogenesis. …

An RNA-sequencing-based transcriptome for a significantly prognostic novel driver signature identification in bladder urothelial carcinoma

D Liu, B Zhou, R Liu - PeerJ, 2020 - peerj.com
… majority of bladder tumours at … to uncovering novel molecular biomarkers from bulk sequencing
data that have an impact on clinical outcomes by analysing the data at the transcriptome

An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer

SV Lindskrog, F Prip, P Lamy, A Taber… - Nature …, 2021 - nature.com
… The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized
by large … At the transcriptomics level, we identified four main classes of NMIBC with the …

Independent component analysis for unraveling the complexity of cancer omics datasets

N Sompairac, PV Nazarov, U Czerwinska… - International Journal of …, 2019 - mdpi.com
… bulk transcriptome, which allows studying the properties of tumor … of bladder cancer,
decomposition of bulk tumors into 20 … of independent component analysis to tumor transcriptomes

Genomic and transcriptomic profiling of high-risk bladder cancer reveals diverse molecular and microenvironment ecosystems

K Meghani, Y Yu, N Frydenlund, EZ Li, B Choy… - bioRxiv, 2024 - biorxiv.org
… Employing phylogenetic analysis, we uncovered microbial species within the bladder
TME of one … NanoString GeoMx human whole transcriptome atlas32 to differentiate tumor-specific …

Integrated single‐cell and spatial transcriptomic profiling reveals higher intratumour heterogeneity and epithelial–fibroblast interactions in recurrent bladder cancer

ZD Shi, Z Sun, ZB Zhu, X Liu, JZ Chen… - Clinical and …, 2023 - Wiley Online Library
landscape of recurrent BLCA are currently lacking. We sought to analyse whole-transcriptome
data … Analysing the integrated data using principal component analysis (PCA) reduced the …

Subtype-associated epigenomic landscape and 3D genome structure in bladder cancer

T Iyyanki, B Zhang, Q Wang, Y Hou, Q Jin, J Xu… - Genome biology, 2021 - Springer
… the genome-wide transcriptome, enhancer landscape, and … and basal subtypes of bladder
cancer. Furthermore, we report … C in both bladder cancer cell lines and primary patient tumors. …

Identification and validation of prognostic signature genes of bladder cancer by integrating methylation and transcriptomic analysis

D Chatterjee, SI Mou, T Sultana, MI Hosen… - Scientific Reports, 2024 - nature.com
bladder cancer patients by exploiting transcriptome analysis, … principal components analysis
(PCA) of the transcriptome data … genes may refine the molecular landscape, contributing to a …

Data-driven human transcriptomic modules determined by independent component analysis

W Zhou, RB Altman - BMC bioinformatics, 2018 - Springer
… modules for such analysis. We apply independent component analysis to the large collection
of … based on the human transcriptome (20,089 genes), and identified a set of 139 functional …