The two-stage induced membrane technique became widely accepted in treatment of infected nonunion. The aim of this study was to evaluate the outcomes of the induced membrane technique using combined free fibular and iliac bone graft in treatment of infected nonunion of long bones of the lower limb. This study comprised 45 consecutive patients (27 femoral, 18 tibial) with infected nonunion of long bones of the lower limb. The mean age of the patients was 35 years. There were 40 males and 5 females. The right side was affected in 30 patients. Comorbidities were present in 22 patients. Thirty cases were smokers. There were 35 cases with diaphyseal fractures and 10 cases with metaphyseal fractures. There were 30 cases with open fractures, 22 patients were treated by intramedullary nail, and 18 patients by plate and screws, while the other 5 patients were previously treated conservatively. The mean follow-up period was 26 ± 5.7 months. The mean defect was 8.16 ± 2.32 cm. The mean interval between the first and the second stage was 7.07 ± 0.79 weeks. The mean time of graft consolidation was 27.4 ± 6.76 weeks after the second stage. The average external fixation index was 1.5 months/cm. Sound union was achieved in 93.3%.The pin tract infection had occurred in all cases. There were residual limb shortening (15.6%), valgus ankle deformity (6.7%), loss of range of knee flexion (33.3%), and refracture (4.4%). No donor site morbidity in either iliac or fibular sites had occurred. Induced membrane technique with autogenous grafting is an alternative biological pathway proved to be effective in the treatment of infected nonunion of long bone of the lower limb with the added value of the use of free fibular graft in such cases.