Induction of Taxol biosynthesis by Aspergillus terreus, endophyte of Podocarpus gracilior Pilger, upon intimate interaction with the plant endogenous microbes
ASA El-Sayed, S Safan, NZ Mohamed, L Shaban… - Process …, 2018 - Elsevier
Twenty-four endophytic fungal isolates recovered from Podocarpus gracilior were screened
for Taxol biosynthetic potency. Among these endophytes, three isolates of Aspergillus
terreus EFB108, EFB59, EFB14 recovered from P. gracilior cork, leaves and twigs,
respectively, were reported as potent Taxol producers. The chemical identity of A. terreus
extracted Taxol was verified from the HPLC, NMR and FTIR analyses, with strong cytotoxic
activity for HEPG2 and MCF7 cell lines (IC 50 4.5–6.5 nM). Upon nutritional of A. terreus …
for Taxol biosynthetic potency. Among these endophytes, three isolates of Aspergillus
terreus EFB108, EFB59, EFB14 recovered from P. gracilior cork, leaves and twigs,
respectively, were reported as potent Taxol producers. The chemical identity of A. terreus
extracted Taxol was verified from the HPLC, NMR and FTIR analyses, with strong cytotoxic
activity for HEPG2 and MCF7 cell lines (IC 50 4.5–6.5 nM). Upon nutritional of A. terreus …
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