Aim of this study is to explain the role of exogenous application of salicylic acid and kinetin in increasing Phaseolus vulgaris resistance against tobacco necrosis virus (TNV). Two-week-old Phaseolus vulgaris plants treated with 0.1, 0.5 and 1 mm salicylic acid and 0.05, 0.1 and 0.5 mm kinetin, showed partial inhibition of the accumulation of local lesion virus in infected primary bean leaves. This inhibition was accompanied with an increase in the peroxidases activity, especially at the low concentration used of early treatment salicylic acid and kinetin compared with the un-treated control plants. In addition, the accumulation of total soluble protein contents were increased in comparison with the untreated control plants.