Solid organ transplantation is widely accepted as an effective treatment for end organ
failure. Although the treatment with immunosuppressive drugs has undoubtedly greatly
improved graft survival, chronic rejection still has considerable impact on long term outcome.
This, together with the undesirable side effects associated with life long treatment with
immunosuppressive drugs, have significant implications for long term outcomes. In a small
number of patients, drug non-compliance as well as controlled reduction or removal of …