Infectious norovirus is chronically shed by immunocompromised pediatric hosts
Noroviruses are a leading cause of gastroenteritis worldwide. Although infections in healthy
individuals are self-resolving, immunocompromised individuals are at risk for chronic
disease and severe complications. Chronic norovirus infections in immunocompromised
hosts are often characterized by long-term virus shedding, but it is unclear whether this shed
virus remains infectious. We investigated the prevalence, genetic heterogeneity, and
temporal aspects of norovirus infections in 1140 patients treated during a 6-year period at a …
individuals are self-resolving, immunocompromised individuals are at risk for chronic
disease and severe complications. Chronic norovirus infections in immunocompromised
hosts are often characterized by long-term virus shedding, but it is unclear whether this shed
virus remains infectious. We investigated the prevalence, genetic heterogeneity, and
temporal aspects of norovirus infections in 1140 patients treated during a 6-year period at a …