The impact of cell culture technology has been immense in the field of research and
pharmaceutical sciences. Suitable environmental conditions are paramount need in order to
maintain the cell line in an in-vitro condition. Since the biological processes are highly
susceptible to acid-base chemistry, variations among the factors will have a severe effect on
cellular integrity that often leads to hypercapnia and senescence of the cells. pH regulation
in the cell culture environment is a fundamental biological phenomenon of great significance …