Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients
M Rotger, S Colombo, H Furrer, G Bleiber… - Pharmacogenetics …, 2005 - journals.lww.com
Background Efavirenz (EFV) and nevirapine (NVP) are metabolized by cytochrome P450
2B6 (CYP2B6). Allele 516 G> T (Gln172His) is associated with diminished activity of this
isoenzyme, and may lead to differences in drug exposure. Methods We evaluated this allele
as a pharmacogenetic marker of EFV and NVP pharmacokinetics and EFV toxicity in 167
participants receiving EFV and 59 receiving NVP recruited within the genetics project of the
Swiss HIV Cohort Study. Drug concentrations were measured in plasma and in peripheral …
2B6 (CYP2B6). Allele 516 G> T (Gln172His) is associated with diminished activity of this
isoenzyme, and may lead to differences in drug exposure. Methods We evaluated this allele
as a pharmacogenetic marker of EFV and NVP pharmacokinetics and EFV toxicity in 167
participants receiving EFV and 59 receiving NVP recruited within the genetics project of the
Swiss HIV Cohort Study. Drug concentrations were measured in plasma and in peripheral …
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