Influence of a low-molecular-weight heparin derivative on the nitric oxide levels and apoptotic DNA damage in adriamycin-induced cardiac and renal toxicity
PR Deepa, P Varalakshmi - Toxicology, 2006 - Elsevier
The spectrum of the anti-apoptotic potential of heparin is currently under scrutiny in various
tissues and under various pathological situations. In this study, the role of a low-molecular-
weight heparin derivative (LMWH), certoparin in adriamycin-induced oxidative DNA damage
has been evaluated in the cardiac and renal tissues. Two groups of male albino rats of the
Wistar strain (140±10g) received a single intravenous injection of adriamycin (7.5 mg/kg),
and one of them received low-molecular-weight heparin (Certoparin Sodium, 300μg/day/rat …
tissues and under various pathological situations. In this study, the role of a low-molecular-
weight heparin derivative (LMWH), certoparin in adriamycin-induced oxidative DNA damage
has been evaluated in the cardiac and renal tissues. Two groups of male albino rats of the
Wistar strain (140±10g) received a single intravenous injection of adriamycin (7.5 mg/kg),
and one of them received low-molecular-weight heparin (Certoparin Sodium, 300μg/day/rat …