A growing focus in modern materials science is the attempt to transfer principles found in nature into new technological concepts with the goal of producing novel materials with tailored mechanical properties. One of these principles used in nature is the concept of sacrificial bonding (i.e. non-covalent cross-links that rupture prior to the protein backbone), which is associated with increased toughness in many biological materials. In the present work, the influence of the number and distribution of sacrificial bonds (SBs) on three main mechanical parameters—strength, work to fracture and apparent stiffness—is investigated in a simple model system using computer simulations. The results show that the work to fracture is mainly determined by the number of SBs present in the system, while the apparent stiffness and, to a lesser extent, the strength is altered when the distribution of SBs is changed.