The purpose of this study is to determine the influence of studying while working and the learning motivation toward the academic achievement of college students majoring Information System at STMIK Royal Kisaran. The data collection method was using random sampling survey to regular students in the range of semesters 2, 4, 6 and 8. A total of 101 respondents were taken as samples and filled out the online questionnaire as the instrument of this study. The instrument testing was using validity and reliability test, and the results of each item are valid. The analysis method used in this study is a classic assumption test that is strengthened by normality test, multicollinearity test, heteroscedasticity test and t-test hypothesis testing. From the results of the study it was found that study while working turned out to have no influence on academic achievement. Learning motivation significantly has an influence to academic achievement of students majoring Information System of STMIK Royal Kisaran. The learning motivation has an influence of 7.8% on academic achievement and the rest is an unknown predictor in this study.