Information theoretic aspects of cryo-electron microscopy
JM Pereira - 2019 - search.proquest.com
2019•search.proquest.com
In the problem of single particle reconstruction in cryo-electron microscopy (cryo-EM), we
want to recover the 3D electrostatic potential of a molecule from noisy 2D projections along
unknown random viewing directions. A similar problem is multi-reference alignment (MRA),
where we want to recover a signal from noisy circularly shifted copies, and the circular shifts
are also unknown.
want to recover the 3D electrostatic potential of a molecule from noisy 2D projections along
unknown random viewing directions. A similar problem is multi-reference alignment (MRA),
where we want to recover a signal from noisy circularly shifted copies, and the circular shifts
are also unknown.
Abstract
In the problem of single particle reconstruction in cryo-electron microscopy (cryo-EM), we want to recover the 3D electrostatic potential of a molecule from noisy 2D projections along unknown random viewing directions. A similar problem is multi-reference alignment (MRA), where we want to recover a signal from noisy circularly shifted copies, and the circular shifts are also unknown.
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