Inhibiting effect of zinc oxide nanoparticles on advanced glycation products and oxidative modifications: a potential tool to counteract oxidative stress in …
JM Ashraf, MA Ansari, S Fatma, SMS Abdullah… - Molecular …, 2018 - Springer
Molecular Neurobiology, 2018•Springer
Advanced glycation end products (AGEs) are implicated in several central nervous system
(CNS) pathologies including Alzheimer and Parkinson's diseases. In the face-off of AGE
menace, we have attempted to investigate the zinc oxide nanoparticle (ZnONP) role in
inhibition of AGE formation. Synthesized ZnONPs were used to investigate the inhibitory
effects on AGE formation. The inhibitory effects of ZnONPs on AGE formation were
determined by biophysical immunological and biochemical techniques. The results showed …
(CNS) pathologies including Alzheimer and Parkinson's diseases. In the face-off of AGE
menace, we have attempted to investigate the zinc oxide nanoparticle (ZnONP) role in
inhibition of AGE formation. Synthesized ZnONPs were used to investigate the inhibitory
effects on AGE formation. The inhibitory effects of ZnONPs on AGE formation were
determined by biophysical immunological and biochemical techniques. The results showed …
Abstract
Advanced glycation end products (AGEs) are implicated in several central nervous system (CNS) pathologies including Alzheimer and Parkinson’s diseases. In the face-off of AGE menace, we have attempted to investigate the zinc oxide nanoparticle (ZnONP) role in inhibition of AGE formation. Synthesized ZnONPs were used to investigate the inhibitory effects on AGE formation. The inhibitory effects of ZnONPs on AGE formation were determined by biophysical immunological and biochemical techniques. The results showed that ZnONP is a potential anti-glycating agent inhibiting AGE formation as well as protecting the protein structure from change. Therefore, our findings suggest ZnONPs may be used as a therapeutic in resolving the AGE role in CNS-related complications.
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