Inhibition of DNA methylation promotes breast tumor sensitivity to netrin‐1 interference
In a number of human cancers, NTN 1 upregulation inhibits apoptosis induced by its so‐
called dependence receptors DCC and UNC 5H, thus promoting tumor progression. In other
cancers however, the selective inhibition of this dependence receptor death pathway relies
on the silencing of pro‐apoptotic effector proteins. We show here that a substantial fraction
of human breast tumors exhibits simultaneous DNA methylation‐dependent loss of
expression of NTN 1 and of DAPK 1, a serine threonine kinase known to transduce the …
called dependence receptors DCC and UNC 5H, thus promoting tumor progression. In other
cancers however, the selective inhibition of this dependence receptor death pathway relies
on the silencing of pro‐apoptotic effector proteins. We show here that a substantial fraction
of human breast tumors exhibits simultaneous DNA methylation‐dependent loss of
expression of NTN 1 and of DAPK 1, a serine threonine kinase known to transduce the …
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