Inhibition of acid sphingomyelinase increases regulatory T cells in humans
T Wiese, F Dennstädt, C Hollmann… - Brain …, 2021 - academic.oup.com
Genetic deficiency for acid sphingomyelinase or its pharmacological inhibition has been
shown to increase Foxp3+ regulatory T-cell frequencies among CD4+ T cells in mice. We
now investigated whether pharmacological targeting of the acid sphingomyelinase, which
catalyzes the cleavage of sphingomyelin to ceramide and phosphorylcholine, also allows to
manipulate relative CD4+ Foxp3+ regulatory T-cell frequencies in humans. Pharmacological
acid sphingomyelinase inhibition with antidepressants like sertraline, but not those without …
shown to increase Foxp3+ regulatory T-cell frequencies among CD4+ T cells in mice. We
now investigated whether pharmacological targeting of the acid sphingomyelinase, which
catalyzes the cleavage of sphingomyelin to ceramide and phosphorylcholine, also allows to
manipulate relative CD4+ Foxp3+ regulatory T-cell frequencies in humans. Pharmacological
acid sphingomyelinase inhibition with antidepressants like sertraline, but not those without …
[PDF][PDF] Inhibition of acid sphingomyelinase increases regulatory T cells in humans
JR Seibel, M Buttmann12, A Menke… - 2021 - researchgate.net
Genetic deficiency for acid sphingomyelinase or its pharmacological inhibition has been
shown to increase Foxp3+ regulatory T cell frequencies among CD4+ T cells in mice. We
now investigated whether pharmacological targeting of the acid sphingomyelinase, which
catalyzes the cleavage of sphingomyelin to ceramide and phosphorylcholine, also allows to
manipulate relative CD4+ Foxp3+ regulatory T cell frequencies in humans. Pharmacological
acid sphingomyelinase inhibition with antidepressants like sertraline, but not those without …
shown to increase Foxp3+ regulatory T cell frequencies among CD4+ T cells in mice. We
now investigated whether pharmacological targeting of the acid sphingomyelinase, which
catalyzes the cleavage of sphingomyelin to ceramide and phosphorylcholine, also allows to
manipulate relative CD4+ Foxp3+ regulatory T cell frequencies in humans. Pharmacological
acid sphingomyelinase inhibition with antidepressants like sertraline, but not those without …
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