Inhibition of bovine brain acetylcholinesterase by aluminum.
Brazilian Journal of Medical and Biological Research= Revista …, 1994•europepmc.org
We report the in vitro inhibitory effect of very low concentrations of aluminum salts (IC50= 4.1
x 10 (-12 M) on bovine brain acetylcholinesterase (AChE). The enzymatic assays were
performed using acetylcholine bromide in a buffered pH 7.4 solution at 37 degrees C. The
relevant enzyme interacting species is the Al3+ ion, whose concentrations were fixed at pM
levels by a citrate metal ion buffer system. The IC50 demonstrates that Al3+ is a potent
inhibitor of AChE.
x 10 (-12 M) on bovine brain acetylcholinesterase (AChE). The enzymatic assays were
performed using acetylcholine bromide in a buffered pH 7.4 solution at 37 degrees C. The
relevant enzyme interacting species is the Al3+ ion, whose concentrations were fixed at pM
levels by a citrate metal ion buffer system. The IC50 demonstrates that Al3+ is a potent
inhibitor of AChE.
We report the in vitro inhibitory effect of very low concentrations of aluminum salts (IC50= 4.1 x 10 (-12 M) on bovine brain acetylcholinesterase (AChE). The enzymatic assays were performed using acetylcholine bromide in a buffered pH 7.4 solution at 37 degrees C. The relevant enzyme interacting species is the Al3+ ion, whose concentrations were fixed at pM levels by a citrate metal ion buffer system. The IC50 demonstrates that Al3+ is a potent inhibitor of AChE.
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